antifungal activity of zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition
نویسندگان
چکیده
objective(s): the aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (slns) containing zataria multiflora essential oil (zeo). materials and methods: in this study, z. multiflora essential oil-loaded solid lipid nanoparticles (ze-slns) were prepared to improve its efficiency in controlling some fungal pathogens. slns containing z. multiflora essential oil were prepared by high shear homogenization and ultra sound technique. zeo-slns contained 0.03% zeo in 5% of lipid phase (glyceryl monostearate-gms and precirol® ato 5).tween 80 and poloxamer 188 (2.5% w/v) were used as surfactant in the aqueous phase. the antifungal efficacy of ze-slns and zeo was compared under in vitro conditions. results:the particle size of ze-slns was around 255.5±3 nm with pdi of 0.369±0.05 and zeta potential was about -37.8±0.8 mv. encapsulation efficacy of ze-slns in crystalline form was 84±0.92%. the results showed that the zeo and ze-slns had 54 and 79% inhibition on the growth of fungal pathogens, respectively. the minimum inhibitory concentration (mic) under in vitro conditions for the zeo on the fungal pathogens of aspergillus ochraceus, aspergillus niger, aspergillus flavus, alternaria solani, rhizoctonia solani, and rhizopus stolonifer was 300, 200, 300, 200, 200 and 200 ppm, respectively, for ze-slns, it was 200, 200, 200, 100, 50 and 50 ppm. the antifungal efficacy of ze-slns was significantly more than zeo. conclusion: our results showed that the slns were suitable carriers for z. multiflora essential oil in controlling the fungal pathogens and merits further investigation.
منابع مشابه
Antifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition
Objective(s): The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). Materials and Methods: In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in controlling some fungal pathogens. SLNs containing Z. multiflora essential ...
متن کاملAntifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition
OBJECTIVES The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). MATERIALS AND METHODS In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in controlling some fungal pathogens. SLNs containing Z. multiflora essential oi...
متن کاملAntibacterial Activity of Silver Nanoparticles and Their Combination with Zataria multiflora Essential Oil and Methanol Extract
BACKGROUND Against a variety of antimicrobial resistant pathogens, the scientists attempted substitution of antimicrobial medicine with various nanoparticles and plant-based antibacterial substances. OBJECTIVES The aim of this study was to assess the antibacterial effects of silver nanoparticles solely and in combination with Zataria multiflora essential oil and methanolic extract on some pho...
متن کاملChemical Composition and Antifungal Activity of Essential Oil of Zataria Multiflora
Background: Aspergillus flavus is a toxic contaminant in foods, which can induce mutagenic, teratogenic, and carcinogenic effects. In last decades, synthetic fungicides have been used for inhibition of fungal growth in plants. The public attention was also attracted to contamination of food chain by these chemicals. Therefore, in the current study, we decided to use Zataria multiflora (ZM) esse...
متن کاملIn Vitro Anti-Candida Activity of Zataria multiflora Boiss
Zataria multiflora Boiss known as Avishan Shirazi (in Iran) is one of the valuable Iranian medicinal plants. The aim of study was to evaluate anti-Candida activity of Z. multiflora against different species of Candida in vitro. Anti-Candida activity of the aqueous, ethanolic and methanolic maceration extract of the aerial parts of Z. multiflora Boiss was studied in vitro. Anti-Candida activity ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۹، شماره ۱۱، صفحات ۱۲۳۱-۱۲۳۷
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023